Established in 1978 as the College of Radiologic Technology at Emilio Aguinaldo College, the College initially offered the Associate in Radiologic Technology (ART) program, training students as X-ray Technologists. Ownership transferred to the De La Salle Brothers in 1987, and the Bachelor of Science in Radiologic Technology (BSRT) was introduced in 1989. The program saw continued success, with graduates excelling in licensure examinations.
In 2000, administration moved to DLSMHSI, prompting a name change to the College of Medical Radiation Technology. The college has since flourished, boasting a state-of-the-art laboratory and earning recognition from the Professional Regulation Commission as the Top 1 Performing School for Radiologic Technology in the Philippines. Renamed the College of Medical Imaging and Therapy in 2018, it offers programs in BS Radiologic Technology and BS Nuclear Medicine Technology, emphasizing accurate and safe radiation utilization in both imaging and therapy.